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  • Title: Burchellin: effects on Triatoma infestans and on Trypanosoma cruzi within this vector.
    Author: Cabral MM, Azambuja P, Gottlieb OR, Kleffmann T, Garcia ES, Schaub GA.
    Journal: Parasitol Res; 2001 Sep; 87(9):730-5. PubMed ID: 11570558.
    Abstract:
    Supplementation of blood with the neolignan burchellin (50 microg/ml), a compound from the arboreous Lauraceae Aniba burchelli, affected the ingestion of blood and the course of excretion of fourth- and fifth-instar larvae of Triatoma infestans, the latter especially within the first 4 h after feeding. The total resultant weight loss of treated fourth instars within 24 and 48 h after feeding was only 24% and 28% vs 41% and 48%, respectively, in untreated bugs. In fifth instars, the total weight losses of untreated bugs within 24 and 48 h after feeding were 38% and 41% whereas the weight of treated bugs decreased by 28% and 34%, respectively. In a treatment of Trypanosoma cruzi-infected fourth instars, burchellin significantly reduced the population density of the established infection in the rectum at 5 and 10 days after feeding. This was especially due to a significant increase in the number of the main dividing stage, the epimastigote.
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