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  • Title: Amino acid substitution within the VP7 protein of G2 rotavirus strains associated with failure to serotype.
    Author: Gómara MI, Cubitt D, Desselberger U, Gray J.
    Journal: J Clin Microbiol; 2001 Oct; 39(10):3796-8. PubMed ID: 11574622.
    Abstract:
    Rotavirus strains collected in the United Kingdom during the 1995-1996 season and genotyped as G2 by reverse transcription-PCR failed to serotype in enzyme-linked immunosorbent assays using three different G2-specific monoclonal antibodies. The deduced amino acid sequences of the antigenic regions A (amino acids 87 to 101), B (amino acids 142 to 152), and C (amino acids 208 to 221) of VP7 revealed that a substitution at position 96 (Asp-->Asn) correlated with the change in ability to serotype these G2 strains.
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