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  • Title: Quinoline alkaloids and other constituents of Melicope semecarpifolia with antiplatelet aggregation activity.
    Author: Chen IS, Chen HF, Cheng MJ, Chang YL, Teng CM, Tsutomu I, Chen JJ, Tsai IL.
    Journal: J Nat Prod; 2001 Sep; 64(9):1143-7. PubMed ID: 11575945.
    Abstract:
    Three new quinoline alkaloids, 2-acetylevolitrine (1), 2-acetylpteleine (2), and semecarpifoline (3), along with 26 known compounds were isolated from the root bark of Melicope semecarpifolia. The structures of 1-3 were elucidated by means of spectral analysis. In addition, (2S)-(--)-7,8-dimethoxyplatydesmine (4), cis-(+)-7,8-dimethoxymyrtopsine (5), and (3R)-(--)-8,9-dimethoxygeibalansine (6) were isolated as new natural products. Several of these isolates were determined as exhibiting significant antiplatelet aggregation activities in vitro.
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