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  • Title: Cytopathic effects of non-syncytium-inducing and syncytium-inducing human immunodeficiency virus type 1 variants on different CD4(+)-T-cell subsets are determined only by coreceptor expression.
    Author: Kwa D, Vingerhoed J, Boeser-Nunnink B, Broersen S, Schuitemaker H.
    Journal: J Virol; 2001 Nov; 75(21):10455-9. PubMed ID: 11581413.
    Abstract:
    In peripheral blood mononuclear cells, syncytium-inducing (SI) human immunodeficiency virus type 1 (HIV-1) infected and depleted all CD4(+) T cells, including naive T cells. Non-SI HIV-1 infected and depleted only the CCR5-expressing T-cell subset. This may explain the accelerated CD4 cell loss after SI conversion in vivo.
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