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  • Title: [Effect of Silybum marianum oil and legalon on lipid peroxidation and liver antioxidant systems in rats intoxicated with carbon tetrachloride].
    Author: Batakov EA.
    Journal: Eksp Klin Farmakol; 2001; 64(4):53-5. PubMed ID: 11589112.
    Abstract:
    An oil obtained from the seeds of Saint-Mary thistle (Silybum marianum) and the drug legalon (silybinin) prepared from this plant produce an antioxidant effect on liver tissues of rats poisoned with carbon tetrachloride. Legalon (25 mg/kg) and the oil (2000 mg) reduced the level of lipid peroxidation, increased the catalase activity, but did not reduce the concentration of selenium in liver (which decreased as a result of CCl4 intoxication). Legalon significantly increased the activity of superoxide dismutase in liver tissues, while the Saint-Mary thistle oil did not produce such effect.
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