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  • Title: Tetrahydrobiopterin inhibits copper-induced oxidation of low density lipoprotein.
    Author: Sakuma S, Fujimoto Y, Gohda Y, Fujita T.
    Journal: Res Commun Mol Pathol Pharmacol; 2000; 107(5-6):397-406. PubMed ID: 11589366.
    Abstract:
    The effect of tetrahydrobiopterin (BPH4) on Cu2+-induced oxidation of low density lipoprotein (LDL) prepared from rabbit plasma was examined. BPH4 (0.5-10 microM) inhibited the formation of thiobarbituric acid-reactive substances (TBARS) in LDL induced by 5 microM Cu2+ in a dose-dependent manner. BPH4 also suppressed the increase in relative electrophoretic mobility (REM) of LDL in the presence of 5 microM Cu2+. The potency of inhibitions of BPH4 on TBARS formation and REM was the same as or stronger than that of ascorbic acid and alpha-tocopherol, which are known as endogenous inhibitors of LDL oxidation. These results suggest that BPH4 could act as an efficacious endogenous inhibitor of atherogenic LDL modification.
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