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  • Title: All-trans retinoic acid reduces intimal thickening after balloon angioplasty in atherosclerotic rabbits.
    Author: Chen J, He B, Zheng D, Zhang S, Liu J, Zhu S.
    Journal: Chin Med J (Engl); 1999 Feb; 112(2):121-3. PubMed ID: 11593575.
    Abstract:
    OBJECTIVE: To investigate the effects of oral administration of all-trans retinoic acid (ATRA) on inhibition of intimal thickening after balloon angioplasty in the rabbit iliac artery atherosclerotic model. METHODS: Iliac atherosclerosis was induced in 24 rabbits, and balloon angioplasty was performed. At angioplasty, 24 rabbits were randomly divided into four groups (n = 6 per group): Group 1: controls not receiving oral ATRA administration; Group 2: receiving oral ATRA (0.6 mg.kg-1.d-1) administration beginning 1 week prior to angioplasty and continuing for 4 weeks; Group 3: receiving oral ATRA (0.6 mg.kg-1.d-1) administration beginning immediately after angioplasty and continuing for 4 wk; Group 4: receiving oral ATRA (0.6 mg.kg-1.d-1) administration beginning 1 wk after angioplasty and continuing for 4 wk. Values of cross-sectional area, ratio of intimal/medial area and thickness were determined by a computer-based morphometric system, and cell proliferative activity was assessed by 3H-thymidine incorporation. RESULTS: Both the cross-sectional area and the ratio of intimal/medial area and thickness were significantly reduced by ATRA administration compared with control group (P < 0.01). The inhibitory effect is less potent when ATRA is administered 1 week before angioplasty. The ATRA inhibitory effect when administered 1 week after angioplasty is not different significantly form that when administered immediately after angioplasty. The 3H-thymidine incorporation was also decreased in ATRA-treated rabbits compared with controls (P < 0.01). CONCLUSIONS: Oral ATRA administration can be effective in inhibiting intimal thickening after balloon angioplasty. It is reasonable that ATRA should be administered immediately after angioplasty.
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