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  • Title: Suppressing effect of substance P receptor antagonist on sound evoked potentials recorded from the guinea pig cochlea.
    Author: Liang X, Wang Z, Zhang L, Ni D.
    Journal: Chin Med J (Engl); 1999 Feb; 112(2):129-31. PubMed ID: 11593577.
    Abstract:
    OBJECTIVE: To investigate the regulation of SP in the cochlea function. METHODS: Ten adult guinea pigs were used as experimental animals. The perilymph space of the guinea pigs cochlea was perfused with artificial perilymph solution containing 1 microgram/microliter SP receptor antagonist (D-Arg1, D-Pro2, D-Trp7,9, Leu11)-SP (1-11) at a rate of 2.5 microliters/min for 10 min while monitoring cochlear potentials evoked by 4 kHz tone burst. RESULTS: The perfusion of SP antagonist resulted in a suppression of the compound action potential of the auditory nerve (CAP, N1-P1), a prolongation of the N1 latency at threshold and suprathreshold levels, an elevation of the CAP threshold. CONCLUSIONS: These results suggest that SP might play a role as a transmitter or modulator in the cochlear function.
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