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  • Title: Synthesis and antibacterial activity of 5- and 6-hydroxy substituted 4-aminoquinolines and derivatives.
    Author: Meyer T, Lemcke T, Geffken D, Kaulfers PM.
    Journal: Pharmazie; 2001 Sep; 56(9):691-5. PubMed ID: 11593987.
    Abstract:
    The synthesis and antimicrobial activity of 4-amino-8-methylquinolines 8, 11 substituted with a hydroxy- or methoxy-group at 5- and at 6-position have been investigated. The title compounds could be prepared by a six-step procedure according to the literature starting from commercially available anilines 1. The novel 4-aminoquinolines 8,11 exhibited slight antibacterial activity against Gram-positive and Gram-negative bacteria.
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