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  • Title: Myelination of brain in experimental hypothyroidism. An electron-microscopic and biochemical study of purified myelin isolates.
    Author: Malone MJ, Rosman NP, Szoke M, Davis D.
    Journal: J Neurol Sci; 1975 Sep; 26(1):1-11. PubMed ID: 1159453.
    Abstract:
    Myelin development has been studied in the neonatally hypothyroid rat brain by isolation and characterization of purified myelin preparations. The hormone deficiency results in a suppression of compact myelin formation and the persistence of a lighter possibly pro-myelin fraction. The appearance of myelin basic protein was markedly delayed in the hormone-deficient animals and this effect on the basic protein moiety may be responsible for the delayed myelinogenesis.
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