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  • Title: HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.
    Author: Semenza GL.
    Journal: Cell; 2001 Oct 05; 107(1):1-3. PubMed ID: 11595178.
    Abstract:
    Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O(2) homeostasis in animals. A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.
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