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  • Title: The immunology of HIV-infected long-term non-progressors--a current view.
    Author: Paroli M, Propato A, Accapezzato D, Francavilla V, Schiaffella E, Barnaba V.
    Journal: Immunol Lett; 2001 Nov 01; 79(1-2):127-9. PubMed ID: 11595299.
    Abstract:
    Long-term non-progressors (LTNP) are human immunodeficiency virus (HIV)-infected individuals characterized by the absence of disease, low viral loads and stable or even increasing CD4(+) T cell counts for prolonged periods of time. In these subjects, an HIV-specific immune response which is either stronger or directed against a wider array of viral epitopes than that seen in progressors, can be often detected. Here, we summarize the characteristics of HIV-specific CD4(+) and CD8(+) T cell responses in LTNP, and discuss how a highly effective T cell-mediated immune response against HIV might contribute to the establishment of this particular condition.
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