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  • Title: Effect of SpeB and EndoS from Streptococcus pyogenes on human immunoglobulins.
    Author: Collin M, Olsén A.
    Journal: Infect Immun; 2001 Nov; 69(11):7187-9. PubMed ID: 11598100.
    Abstract:
    Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity, while EndoS is highly specific for IgG.
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