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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Eradication of biofilm-forming Staphylococcus epidermidis (RP62A) by a combination of sodium salicylate and vancomycin.
    Author: Polonio RE, Mermel LA, Paquette GE, Sperry JF.
    Journal: Antimicrob Agents Chemother; 2001 Nov; 45(11):3262-6. PubMed ID: 11600396.
    Abstract:
    Staphylococcus epidermidis is a major cause of infections associated with indwelling medical devices. Biofilm production is an important virulence attribute in the pathogenesis of device-related infections. Therefore, elimination of these biofilms is an ideal treatment. Salicylate (5 mM) combined with 1 microg of vancomycin per ml inhibited biofilm formation by S. epidermidis (RP62A) by >or=99.9%. When biofilm-coated polystyrene beads were exposed to 5 mM sodium salicylate and 4 microg of vancomycin per ml (one-half the minimum biofilm eradication concentration), there was a >99.9% reduction in viable count.
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