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  • Title: [Study of TEL-AML1 fusion gene in childhood B-lineage acute lymphoblastic leukemia].
    Author: Niu C, Huang W, Su X.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 1999 Feb; 20(2):61-4. PubMed ID: 11601199.
    Abstract:
    OBJECTIVE: To determine the incidence of TEL-AML1 fusion gene and its role in clinical diagnosis and prognosis of childhood B-lineage acute lymphoblastic leukemia (B-ALL), and to compare the two techniques: nested RT-PCR and dual-color fluorescence in situ hybridization (FISH). METHODS: Nested RT-PCR and dual-color FISH techniques were used to detect TEL-AML1 fusion gene. RESULTS AND CONCLUSION: TEL-AML1 fusion transcript was found in 22.5%(9/40) of patients with B-ALL by RT-PCR. The prognosis of these TEL-AML1 positive patients was relatively good and the complete remission rate was 100%. Both RT-PCR and FISH techniques were proved to be useful for detecting TEL-AML1 fusion gene and suitable for clinical diagnosis and prognosis evaluation.
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