These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The effect of a keto acid supplement on the course of chronic renal failure and nutritional parameters in predialysis patients and patients on regular hemodialysis therapy: the Hungarian Ketosteril Cohort Study.
    Author: Zakar G, Hungarian Ketosteril Cohort Study.
    Journal: Wien Klin Wochenschr; 2001 Sep 17; 113(17-18):688-94. PubMed ID: 11603104.
    Abstract:
    UNLABELLED: The results of the Hungarian Ketosteril follow up cohort study are reported. Aim of the study was to evaluate the feasiblity and effects of a low protein diet supplemented with keto acids/amino acids (KA) on the progression of chronic renal failure (CRF) in a large group of predialysis patients (PRE) and on nutritional parameters in both PRE and dialysis patients (DIA). PATIENTS AND METHODS: PRE (N = 181) and DIA (N = 42) patients treated in 47 hungarian nephrology and dialysis centres were followed through 18 months. A standardized dietary and KA supplementation protocol was prescribed (PRE group: KA 0.1 g/kgBW/day; dietary protein 0.5-0.6 g/kgBW/day; energy 30 kcal/kgBW/day; DIA group: dietary protein 1.2 g/kgBW/day, KA and energy prescription similar to the PRE group). Progression of CRF was evaluated by linear regression analysis of 1/serum Creatinine (sCr) values versus time, subjective global assessment (SGA) scores were analyzed by Chi-square test, other metabolic parameters (serum albumin, parathormone [iPTH], Ca/P product) were analyzed by descriptive statistics. RESULTS: In PRE patients slopes of 1/sCr were in the range of 0.0022-0.0015 [100 ml/mg x month], showing no significant difference in the three subgroups of PRE patients (Group A: initial serum creatinine (sCr) 201-400, Group B: sCr 401-600, Group C: sCr > 600 mmol/L). Serum albumin levels below 35 g/L improved significantly, iPTH levels showed a tendency to improve during KA supplementation. In dialysis patients there was an improvement in SGA scores. Midweek predialysis blood urea and sCr levels did not change significantly. CONCLUSIONS: In a large group of PRE patients prescription of a low protein diet supplemented with KA is feasible and leads to a diminution of 1/sCr equation slopes independent from the degree of renal dysfunction, suggesting a retardation in the rate of CRF progression. There was an improvement in nutritional parameters both in PRE and DIA patients, the latter being characterized by improved SGA scores.
    [Abstract] [Full Text] [Related] [New Search]