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  • Title: Synthesis and cytotoxicity on sensitive and doxorubicin-resistant cell lines of new pyrrolo[2,1-c][1,4]benzodiazepines related to anthramycin.
    Author: Langlois N, Rojas-Rousseau A, Gaspard C, Werner GH, Darro F, Kiss R.
    Journal: J Med Chem; 2001 Oct 25; 44(22):3754-7. PubMed ID: 11606141.
    Abstract:
    A new 7,8-methylenedioxy analogue (4) of (+)-porothramycin B (2) and its water-soluble sodium bisulfite derivative (15) have been synthesized in high yields and have been shown to exhibit high cytotoxic activities against several tumor cell lines. The new pyrrolo[2,1-c][1,4]benzodiazepine 4 was as effective against the resistant cell lines as against the doxorubicin-sensitive cell lines tested.
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