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  • Title: Temporal relationships critical to progesterone-induced acceleration of ovum transport.
    Author: de Vargas MI, Hodgson BJ, Pauerstein CJ.
    Journal: Obstet Gynecol; 1975 Sep; 46(3):299-301. PubMed ID: 1161233.
    Abstract:
    Previous investigators have demonstrated that 2.5 mg fo progesterone, administered intramuscularly to rabbits on the day of ovulation and the 2 preceding days (Days -2, -1, and 0) significantly and consistently accelerates ovum transport. In contrast, when given on the day of ovulation and the 2 following days (Days 0, +1, and +2), progesterone does not accelerate ovum transport. The experiments reported were designed to define more precisely the temporal relationships critical to progesterone-induced acceleration of tubal ovum transport. Our observations suggest 3 important conclusions: 1) Progesterone, when given at least 1 day, and not more than 2 days, prior to ovulation does induce accelerated ovum transport. 2) The progesterone responsive mechanism is dose dependent. 3) The acceleration is partially antagonized if progesterone treatment is begun 3 days prior to ovulation. These experiments were designed to determine the time relationship of progesterone administration to ovulation and to ovum transport rates in the rabbit. Ovulation was induced in New Zealand white does by iv injection of 100 units of human chorionic gonadotropin (hCG). The day this was given was designated Day 0. All animals were killed 24 hours after injection, oviducts removed, and ova counted. Ova in the uterine horns were also counted and ovulation points on the ovaries recorded. In control animals all ova were recovered in the oviducts. When 2.5 mg progesterone had been given 1 or 2 days before Day 0 only 34% of the ova were in the oviducts and 41% were in the uteri. When 2.5 mg progesterone was given 3 days before or on Day 0, the accelerated ovum transport did not occur. Treatment by progesterone for 4 days, starting 3 days before ovulation, diminished ovum acceleration. When 7.5 mg progesterone were given in a single dose either 3 days before or on Day 0, ovum transport was not altered but when given 1 or 2 days before Day 0 maximum ovum acceleration was induced. Results show that the effects of progesterone on ovum transport are related to both time and dose administered. To induce acceleration of ovum transport progesterone injection must be given earlier than 12 hours but not more than 60 hours before ovulation (p less than .001). This result is dose-dependent and is partially reduced if progesterone is given 3 days prior to ovulation. If the same holds true for humans, the results indicate that progester one should be given as a single dose within 36-60 hours prior to ovulation or about the time of the blood estrogen peak.
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