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  • Title: Systolic prolapse of the mitral valve in Noonan's syndrome.
    Author: Towne WD, Fabian JS, Rosen KM, Rahimtoola SH.
    Journal: Am Heart J; 1975 Oct; 90(4):499-502. PubMed ID: 1163443.
    Abstract:
    A thirty-five-year-old woman with Noonan's syndrome (Turner phenotype with normal chromosome pattern) had mitral valve prolapse and mitral insufficiency associated with the auscultatory findings of a midsystolic click and late systolic murmur. Selective left-ventricular angiocardiography also showed eccentric hypertrophy of the left ventricle. To our knowledge, this is the first reported instance of mitral valve prolapse occurring in association with Noonan's syndrome.
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