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  • Title: The effect of prostaglandin F2alpha on the placental progesterone level in midtrimester abortion.
    Author: Aleem FA, Schulman H, Saldana LR, Hung HC.
    Journal: Am J Obstet Gynecol; 1975 Sep 15; 123(2):202-5. PubMed ID: 1163583.
    Abstract:
    A gas chromatograph method has been used for the determination of placental progesterone levels in 14 patients aborted at midtrimester by intra-amniotic instillation of prostaglandin F1alpha, also from a control group (five patients) aborted surgically by dilatation and suction. The results showed that the mean %/- S.E. of placental progesterone in the prostaglandin group was 1.45 mug +/- 0.09 per 1 Gm. of placental tissue, whereas the mean +/- S.E. of the placental progesterone in the surgically aborted group was 5.22 +/- 0.31 mug per 1 Gm. of placental tissue. The difference between the two groups was significant: P EQUALS 0.0001. This low level of placental progesterone in the prostaglandin abortion group could explain the sharp decline of the progesterone levels in the peripheral blood during abortion by intra-amniotic instillation of prostaglandin F2alpha, as observed by our group1, 2 and others.3(-5) A gas chromatograph method has been used for the determination of placental progesterone levels in 14 patients aborted at midtrimester by intraamniotic instillation of (PGF) prostaglandin F2alpha and also from a control group (5 patients) aborted surgically by dilatation and suction. The results showed that the mean + or - S.E. of placental progesterone in the PG group was 1.45 mcg + or - 0.09/1 gm of placental tissue, whereas the mean + or - S.E. of the placental progesterone in the surgically aborted group was 5.22 + or - 0.31 mcg/1 gm of placental tissue. The difference between the 2 groups was significant: P=0.0001. This low level of placental progesterone in the PG abortion group could explain the sharp decline of the progesterone levels in the peripheral blood during abortion by intraamniotic instillation of PGF2alpha.
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