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  • Title: [Clinico-functional evaluation of hypotensive effect of carvedilol in elderly patients with mild and moderate arterial hypertension].
    Author: Gel'tser BI, Kotel'nikov VN, Volkonskaia OG, Bobyleva MV, Khitrina VV, Khludeeva EA.
    Journal: Ter Arkh; 2001; 73(9):13-7. PubMed ID: 11642072.
    Abstract:
    AIM: To study a hypotensive activity of carvedilol (dilatrend, Beringer Mannheim GMBH), its influence on 24-h profile of arterial pressure (AP), baroreceptor control of BP and vegetative regulation of the heart in elderly patients with mild and moderate arterial hypertension (AH). MATERIAL AND METHODS: A 3-week monotherapy with carvedilol in a single dose 25 mg/day was conducted in 47 elderly patients with mild or moderate isolated systolic or essential hypertension. The effect of the treatment was assessed by the data of synchronous 24-h monitoring of blood pressure (BP), ECG, by variability of the cardiac rhythm (Cardio Tens, Cardio Tens 01, Meditech, Hungary), baroreceptor regulation of BP (the study of synocarotid areas by the method of "cervical" camera). RESULTS: Carvedilol produced a positive trend in the clinicofunctional indices of the circulation. The hypotensive effect lasted 24 hours in 78.8% of the examinees. The drug had no negative effect on the circadian rhythm of AP, is active early in the morning, did not induce a rise in the hypotonic load or diagnostically significant deviation of ST segment, reduced AP variability, improved vegetative and baroreceptor regulation of blood circulation. CONCLUSION: Carvedilol in a dose 25 mg/day is an effective monotherapy of mild and moderate AH in elderly patients.
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