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  • Title: [Efficacy of OSMO-Adalat in patients with arterial hypertension in combination with kinked precerebral arteries].
    Author: Khirmanov VN, Tiurina TV, Sorokoumov VA, Zakharova IV.
    Journal: Ter Arkh; 2001; 73(9):24-7. PubMed ID: 11642075.
    Abstract:
    AIM: To evaluate effectiveness of OSMO-adalat in combination of arterial hypertension (AH) with kinked precerebral arteries (KPA). MATERIAL AND METHODS: Before and after a 3-month course of OSMO-Adalat in a dose 30 and 60 mg, 28 patients with AH (degree 2-3) and KPA were examined for arterial pressure (AP), dyscirculatory encephalopathy, orthostatic stability, ischemic heart disease, transitory ischemic attacks, side effects of therapy. RESULTS: A complete normalization of AP was achieved in 9(32.1%) patients, in the rest patients the effect was partial. 24-h AP profile improved in all the cases. OSMO-Adalt relieved coronary insufficiency and dyscirculatory encephalopathy, improved tolerance of orthostatic loads. Syncopes, transitory ischemic attacks and strokes were not observed. Severe head ache was the cause of the treatment discontinuation in one patient. CONCLUSIONS: Therapy with OSMO-Adalat of patients with AH combination with KPA provides a good hypotensive effect and relieves symptoms of encephalopathy, myocardial ischemia and orthostatic insufficiency in low risk of side effects.
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