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  • Title: [Antihypertensive effect of enalapril and lisinopril administered in combination with nonsteroid anti-inflammatory agents].
    Author: Savenkov MP, Ivanov SN, Brodskaia SA.
    Journal: Ter Arkh; 2001; 73(9):27-31. PubMed ID: 11642076.
    Abstract:
    AIM: To study the effects of nonsteroid antiinflammatory drugs (NSAID) on antihypertensive activity of ACE inhibitors with different metabolic activity. MATERIAL AND METHODS: 30 patients aged 45-70 years with arterial hypertension of degree I-II who had moderate and high risk of cardiovascular complications and concomitant spinal osteochondrosis with radicular syndrome. 20 patients received sequential treatment. Four variants of the course treatment were used: 1) monotherapy with enalapril maleate (2 mg twice a day); 2) enalapril maleate (5 mg twice a day) in combination with NSAID; 3) monotherapy with lisinopril (10 mg once a day); 4) lisinopril (10 mg once a day in combination with NSAID. 10 patients received enalapril (10 mg once a day) and acetylsalicylic acid (500 and 100 mg). RESULTS: To the end of the treatment week 2 good and satisfactory antihypertensive effect was achieved in 70 and 85% on enalapril and lisinopril, respectively. NSAID addition to enalapril worsened its antihypertensive activity, to lisinopril--the negative effect was much less. CONCLUSION: The data suggest metabolic conception of competitive interaction of ACE inhibitors with NSAID. Therefore, ACE inhibitors should be used differentially in active therapy with NSAID.
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