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  • Title: [Correlation between severity of angina, its stability, and oxidative modification of lipids in patients with ischemic heart disease].
    Author: Syrkin AL, Azizov OA, Drinitsina SV, Frenkel' EE, Solov'eva NP, Dudnik LB, Kliuchnikova TI.
    Journal: Ter Arkh; 2001; 73(9):38-42. PubMed ID: 11642079.
    Abstract:
    AIM: To elucidate the relations between angina severity, stability, concomitant arterial hypertension, diabetes mellitus, plasma oxidation. MATERIAL AND METHODS: The study included 152 patients with stable angina of effort (functional class II-III). Of them, 67 had concomitant arterial hypertension (AH), 20 AH and compensated diabetes mellitus type II, 14 patients with anginal functional class III were admitted to hospital for unstable angina, 11 patients with IHD with unstable angina and 28 healthy donors. The study was made of dynamic features of lipid oxidation using copper-induced plasma oxidation. Lipids were measured with enzyme assays. RESULTS: The degree of LP oxidation increases with aggravation of angina. IHD risk factors activate atherogenic modification of lipids in patients with stable angina. There was no differences between the groups in content of low density lipoproteins cholesterol. CONCLUSION: Plasma resistance to oxidation may serve an additional criterion for assessment of severity and stability of various IHD forms.
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