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  • Title: Sequential use of coccidiostats: effect on development by Eimeria tenella of resistance to amprolium, nicarbazin, Unistat, and zoalene.
    Author: McLoughlin DK, Chute MB.
    Journal: Avian Dis; 1975; 19(3):424-8. PubMed ID: 1164311.
    Abstract:
    A strain of the cecal coccidian of chickens, Eimeria tenella, was propagated serially in chickens fed mash containing amprolium, nicarbazin, Unistat, or zoalene. Each group of chickens received a different coccidiostat on a rotating basis. The strain was propagated through 40 groups of chickens; thus, the strain was intermittently exposed 10 times to each coccidiostat. The end product of this simulated shuttle program of prophylactic anticoccidial medication was a strain resistant to three of the four coccidiostats involved. Resistance to nicarbazin was not evident.
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