These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Serum and plasma insulin levels in zinc-deficient rats following glucose stimulation].
    Author: Roth HP, Kirchgessner M.
    Journal: Int J Vitam Nutr Res; 1975; 45(2):201-8. PubMed ID: 1165165.
    Abstract:
    In three experiments male Sprague-Dawley rats depleted in zinc (2 ppm dietary zinc) for 30 to 35 days had greatly reduced serum insulin levels when compared to ad libitum-fed control animals (100 ppm dietary zinc) but in only one of the experiments when compared to pair-fed control animals (100 ppm dietary zinc) which also had reduced insulin levels. Similarly, in a following study the plasma insulin levels of zinc-deficient animals depleted for 20 days were not different from those of pair-weight control animals (100 ppm dietary zinc). Fifteen minutes after one i.m. glucose injection and 15 minutes after two glucose injections, two hours apart, the zinc-deficient rats showed a higher blood glucose level than the pair-weight controls. The plasma insulin contents also increased after the glucose stimulation but were not significantly different between the zinc-deficient and the zinc-supplemented groups. It is assumed that zinc deficiency lowers the physiological potency of insulin and thereby effects a reduced glucose homeostasis of zinc-deficient rats. This could also be demonstrated by additional studies with zinc-deficient rats which secreted 76 per cent more insulin after a Rastinon injection than control animals though they showed about the same bloodglucose levels.
    [Abstract] [Full Text] [Related] [New Search]