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  • Title: Minimal-lesion nephrotic syndrome with early resistance to steroid therapy.
    Author: Siegel NJ, Gur A, Krassner LS, Kashgarian M.
    Journal: J Pediatr; 1975 Sep; 87(3):377-80. PubMed ID: 1165516.
    Abstract:
    The initial and long-term clinical course of six children with steroid-resistant, minimal-lesion nephrotic syndrome was evaluated. All children experienced remission after two to five weeks of combined cyclophosphamide-prednisone therapy. Following cyclophosphamide treatment, three patients have relapsed and have become steroid sensitive. The clinical outcome was quite favorable. These data suggest: (1) cyclophosphamide may induce a prompt remission in patients with minimal glomerular lesions who have early resistance to corticosteroids; (2) relapses which occur after cyclophosphamide should be treated with prednisone alone, even though the patient was previously steroid resistant; (3) the ultimate outcome is related more to the nature of the histopathologic lesion than to a lack of steroid responsiveness.
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