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  • Title: The central action of intraventricularly (ivc) administered propranolol and phentolamine in rat.
    Author: Kleinrok Z, Ksiazek A, Przesmycki K, Kolasa K.
    Journal: Pol J Pharmacol Pharm; 1975; 27(4):405-12. PubMed ID: 1166021.
    Abstract:
    Propranolol (100mug) ivc together with phentolamine (60 mug) decreased spontaneous locomotor activity and weakened post-nialamide locomotor activity in rat. When applied separately in the above doses, neither of the two compounds had this action. Depression of amphetamine-induced locomotor activity was observed after propranolol (250 mug) together with phetolamine (60 mug). Phentolamine alone, had hypothermic action but when applied together with propranolol, it increased after 4 hrs body temperature. The tested compounds prolonged hexobarbital-induced sleeping time but did not affect noradrenaline or dopamine levels in rat's brain.
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