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  • Title: Potentiation of the hepatotoxic responses to chemicals in alloxan-diabetic rats.
    Author: Hanasono GK, Witschi H, Plaa GL.
    Journal: Proc Soc Exp Biol Med; 1975 Sep; 149(4):903-7. PubMed ID: 1166087.
    Abstract:
    Alloxan diabetes enhances the hepatotoxic response of male rats to chloroform and 1, 1, 2-trichloroethane, but not to trichloroethylene nor 1, 1, 1-trichloroethane. Insulin treatment partially protects the animals against the alloxan-induced enhancement of chloroform hepatotoxicity. Alloxan diabetes also enhances the hepatotoxic response to galactosamine but not to beryllium nor alpha-naphthylisothiocyanate.
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