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  • Title: Combined implantation of particulate dentine, plaster of Paris, and a bone xenograft (Bio-Oss) for bone regeneration in rats.
    Author: Su-Gwan K, Hak-Kyun K, Sung-Chul L.
    Journal: J Craniomaxillofac Surg; 2001 Oct; 29(5):282-8. PubMed ID: 11673923.
    Abstract:
    UNLABELLED: The purpose of this study is to assess the combination of particulate dentine and plaster as bone substitute material in calvarial bone defects in rats, and to compare it with a bone xenograft (Bio-Oss). MATERIAL AND METHODS: Forty rats were assigned randomly to five groups and each group was further divided into two subgroups, 8 and 16 weeks after implantation. The defect was filled with different graft materials in each group: Group 1, defects were filled with particulate dentine and plaster using a 2:1 ratio; Group 2, defects were filled with particulate dentine; plaster, and Bio-Oss using a 2:1:1 ratio; Group 3, defects were filled with plaster and Bio-Oss using a 1:1 ratio; Group 4, defects were filled with Bio-Oss only; and Group 5, untreated control defects. Histological sections and histomorphometric analysis of defects were obtained at 8 and 16 weeks postoperatively. RESULTS: New bone formation was highest in Group 4, followed by Group 3, than Group 2, Group 1, and finally the control group. CONCLUSION: The combination of particulate dentine and plaster is an alternative bone substitute, although it is less effective than Bio-Oss.
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