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  • Title: Multiple sclerosis and elevation of cerebrospinal fluid vaccinia virus antibody.
    Author: Thompson JA, Bray PF, Glasgow LA.
    Journal: Neurology; 1975 Jan; 25(1):94-6. PubMed ID: 1167412.
    Abstract:
    Thirty percent of 33 patients with a clinical diagnosis of multiple sclerosis and an elevation of cerebrospinal fluid (CSF) immunoglobulin G/albumin ratio greater than 2 standard deviations above the mean had elevation of the CSF vaccinia neutralizing antibody titer. Elevated titers were found in 1 of 23 patients with non-multiple sclerosis neurologic diseases and in none of the normal control patients. No linear correlation was found between the magnitude of the relative or absolute CSF immunoglobulin G concentration and the magnitude of the CSF vaccinia neutralizing antibody titers.
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