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  • Title: Polymorphonuclear leukocytes in antibody-dependent cellular cytotoxicity.
    Author: Gale RP, Zighelboim J.
    Journal: J Immunol; 1975 Mar; 114(3):1047-51. PubMed ID: 1167565.
    Abstract:
    Human polymorphonuclear leukocytes (PMN) lyse antibody-coated target cells in an immunologically specific fashion--antibody-dependent cellular cytotoxicity (ADCC). PMN-mediated cytolysis is independent of complement, de novo protein synthesis, and DNA replication. Cytolysis is rapid, detectable at low PMN:target cell ratios, and exceeds lymphocyte-mediated ADCC. The interaction appears to be mediated via an Fc receptor and is inhibited by aggregated gamma-globulin. A role for PMN in host tumor cell immunity is discussed.
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