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  • Title: Negative-antibody paraneoplastic syndrome complicating small cell carcinoma.
    Author: Farrugia ME.
    Journal: Scott Med J; 2001 Aug; 46(4):117-8. PubMed ID: 11676043.
    Abstract:
    The neurological paraneoplastic syndromes represent nonmetastatic complications of cancer and may affect several levels of the nervous system. They are thought to be immunologically-mediated. The syndrome predates the diagnosis of cancer by months to years in two thirds of cases. We report the case of a female patient presenting with a cerebellar syndrome and a sensory neuronopathy on a background of severe weight loss. We searched for occult malignancy and later diagnosed her to be suffering from a paraneoplastic syndrome secondary to small cell carcinoma of the lung. Paraneoplastic antibodies were negative. She was subsequently treated with chemotherapy.
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