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  • Title: Synthesis and antimicrobial evaluation of chalcone and syndrome derivatives of 4(3H)-quinazolinone.
    Author: Bekhit AA, Habib NS, el-Din A, Bekhit A.
    Journal: Boll Chim Farm; 2001; 140(5):297-301. PubMed ID: 11680081.
    Abstract:
    The increasing clinical importance of drug-resistant bacterial pathogens has encouraged additional microbiological and antibacterial research. New chalcone and sydnone derivatives of 4(3H)-quinazolinone were synthesized and evaluated for their antibacterial and antifungal activity. The microorganisms used were Escherichia coli ATCC 25922 as Gram-negative bacteria, Staphylococcus aureus ATCC 19433 as Gram-Positive bacteria and Candida albicans as yeast like fungi. The most potent compound was the nitroso derivative 6b, which exhibits interesting antibacterial and antifungal activities.
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