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  • Title: [Refractory idiopathic cold agglutinin disease successfully treated with intermittent high-dose cyclophosphamide].
    Author: Nakagawa M, Miyagishima T, Kamata T, Arai S, Miura Y, Onishi S, Kishimoto A, Kamishima Y, Choi GH, Kudo M, Okabe M.
    Journal: Rinsho Ketsueki; 2001 Sep; 42(9):713-5. PubMed ID: 11680985.
    Abstract:
    A 56-year-old woman, who had been suffering from idiopathic cold agglutinin disease and treated unsuccessfully with prednisolone and cyclosporine A for 6 months, was referred to our hospital in November 1998. She was given methylprednisolone pulse therapy followed by low-dose cyclophosphamide, but her anemia did not improve. We then began administration of intermittent high-dose cyclophosphamide (1,200 mg/day, every 4 weeks), and this resulted in a dramatic increase of her hemoglobin level and improvement of her symptoms. She is currently receiving 500 mg of cyclophosphamide every 2 months and showing a good response. Intermittent high-dose cyclophosphamide therapy can be an effective treatment for refractory cold agglutinin disease.
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