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  • Title: [Standard therapy of CPT-11 for colorectal cancer].
    Author: Saitoh S, Sakata Y.
    Journal: Gan To Kagaku Ryoho; 2001 Oct; 28(10):1345-51. PubMed ID: 11681240.
    Abstract:
    Irinotecan (CPT-11) is a potent inhibitor of topoisomerase I, and has demonstrated antitumor activity against metastatic colorectal cancer. In phase II studies, CPT-11 showed promising activity. Combining irinotecan with 5-fluorouracil (5-FU) and Leucovorin (LV) has shown benefits for patients with metastatic colorectal cancer CPT-11/5-FU/LV therapy is considered as a standard therapy. Weekly or biweekly administration of CPT-11 is most recommended.
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