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  • Title: Comparison of structural and stereoisomers of apomorphine on stereotyped behavior of the rat.
    Author: Schoenfeld RI, Neumeyer JL, Dafeldecker W, Roffler-Tarlov S.
    Journal: Eur J Pharmacol; 1975 Jan; 30(1):63-8. PubMed ID: 1168137.
    Abstract:
    N-n-propylnorapomorphine (NPA) is 35 times more potent than apomorphine (APO) in producing stereotyped behavior in rats. The effect of NPA is blocked by perphenazine but unaltered by alpha-methyltyrosine pretreatment and is accompanied by a decrease in central dopamine turnover. The activity of APO and NPA appears to be primarily in the (-)-isomer, and is diminished but not lost by removal of either hydroxyl group from the catechol ring system.
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