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  • Title: A new HPLC method to determine Donepezil hydrochloride in tablets.
    Author: Pappa H, Farrú R, Vilanova PO, Palacios M, Pizzorno MT.
    Journal: J Pharm Biomed Anal; 2002 Jan 01; 27(1-2):177-82. PubMed ID: 11682224.
    Abstract:
    A HPLC stability-indicating assay for Donepezil hydrochloride in tablets was developed and validated. Donepezil hydrochloride is a reversible inhibitor of acetylcholinesterase, indicated for the treatment of mild to moderate dementia of the Alzheimer's type. The HPLC method was performed with a reversed phase C18 column, detection at 268 nm and a mixture of methanol, phosphate buffer 0.02 M and triethylamine (50:50:0.5) as mobile phase. Typical retention time for Donepezil was 9 min. The method was statistically validated for linearity, accuracy, precision and selectivity following ICH recommendations. Due to its simplicity and accuracy, the method can be used for routine quality control analysis.
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