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  • Title: Primary Ki-1 lymphoma in the central nervous system.
    Author: Kawamura T, Inamura T, Ikezaki K, Miyazono M, Ishihara S, Fukui M.
    Journal: J Clin Neurosci; 2001 Nov; 8(6):574-7. PubMed ID: 11683612.
    Abstract:
    Large cell anaplastic malignant lymphoma with Ki-1 (CD30) antigen is a new entity among human non-Hodgkin's malignant lymphomas according Updated Kiel Classification and is also a very rare subtype in primary central nervous system (CNS) malignant lymphomas. The precise clinical characteristics and the significance of Ki-1 antigen have yet to be clarified. The authors herein report a case of Ki-1 positive primary T-cell CNS malignant lymphoma. A 49-year-old man presented with multiple mass lesions in the brain on MRI. Immunohistochemical investigations of biopsy specimens from the superior medullary velum revealed a large cell anaplastic T-cell lymphoma positive for Ki-1 antigen. After administering extensive chemo-radiotherapy, the patient has survived for more than 42 months after the onset of symptoms.
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