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  • Title: [Epidural aspergillosis secondary to lung aspergilloma despite long-term itraconazole treatment].
    Author: Jeanrot C, Guigui P, Groussard O, Deburge A.
    Journal: Rev Chir Orthop Reparatrice Appar Mot; 2001 Oct; 87(6):596-600. PubMed ID: 11685151.
    Abstract:
    A 58-year-old man developed spinal cord compression at the T2-T3 level due to an Aspergillus epidural abscess. This presumably immunocompetent patient had been treated for two years by oral itraconazole (200 mg/day) for a lung aspergilloma that occurred seven years after removal of a lung adenocarcinoma. Surgical debridement was performed via a wide posterior approach associated with high-dose amphotericin B. Five months later, the patient's neurological deficit had not improved and the patient died from respiratory failure. Despite a long-term treatment with itraconazole, the infection spread locally from a lung aspergilloma to the epidural space.
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