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  • Title: Dynamic activation of protein function: a view emerging from NMR spectroscopy.
    Author: Wand AJ.
    Journal: Nat Struct Biol; 2001 Nov; 8(11):926-31. PubMed ID: 11685236.
    Abstract:
    Recent developments in solution NMR methods have allowed for an unprecedented view of protein dynamics. Current insights into the nature of protein dynamics and their potential influence on protein structure, stability and function are reviewed. Particular emphasis is placed on the potential of fast side chain motion to report on the residual conformational entropy of proteins and how this entropy can enter into both the thermodynamic and kinetic aspects of protein function.
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