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  • Title: Comparsion of hydroxyindole-O-methyltransferse levels in pineal glands of normal, blinded, and congenitally anophthalmic guiena pigs.
    Author: Farriss BL, Botz LD.
    Journal: Endocrinology; 1975 Jun; 96(6):1595-6. PubMed ID: 1168566.
    Abstract:
    The level of pineal hydroxyindole-O-methyltransferase activity was measured in normal sighted, normal blinded, and congenitally anophthalmic guinea pigs at 1100-1200 and 2300-2400 h. Significant day-night differences were found in the normal sighted and normal blinded guinea pigs; however, the levels were markedly elevated in the normal blinded guinea pigs. The congenitally anophthalmic guinea pigs did not demonstrate a difference between day and night activities. Both the day and night levels of hydroxyindole-O-methyltransferase activities in the latter animals were slightly less than the low daytime levels for the normal, sighted guinea pigs.
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