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  • Title: [Contemporary views on the etiology and pathogenesis of atherosclerosis].
    Author: Draganov V, Balutsov M, Lazarov S.
    Journal: Vutr Boles; 2000; 32(4):25-32. PubMed ID: 11688327.
    Abstract:
    Atherosclerosis is caused by a large range of exogenous and endogenous risk factors and does not result simply from the hypercholesterolemia and the accumulation of lipids. Atherogenesis is a dynamic multifactor and multi-stage inflammatory process, where different cells, cytokines and growth factors interacte as results of endothelial cell damage. This process is characterized by a focal subintimal deposition of lipids and lipoproteins in "foam cells" with a further development of chronic focal inflammation and expanditure of fibrosis, stenosis of the arterial lumen and development of further organ complications. The same are found in 50% of the patients, affected by atherosclerosis and are at the root of the death-rate in USA and Europe.
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