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  • Title: Trypanosoma evansi: demonstration of a transferrin receptor derived from expression site-associated genes 6 and 7.
    Author: Kabiri M, Steverding D.
    Journal: J Parasitol; 2001 Oct; 87(5):1189-91. PubMed ID: 11695395.
    Abstract:
    In Trypanosoma brucei, uptake of host transferrin is mediated by a heterodimeric, glycosylphosphatidylinositol-anchored receptor derived from the 2 expression site-associated genes 6 and 7 (ESAG6 and ESAG7). By using specific antibodies, it is shown here that T. evansi, a trypanosome species transmitted mechanically by biting flies, also expresses a transferrin receptor composed of ESAG6 and ESAG7. The cellular uptake of transferrin in T. evansi is completely inhibited with anti-T. brucei (ESAG6/7 heterodimer) antibodies. The demonstration of a functional ESAG6/7 transferrin receptor in T. evansi supports further its close relationship to T. brucei.
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