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  • Title: A short synthetic pathway to a fully-functionalized southern hemisphere of the antitumor macrolide bryostatin 1.
    Author: Hale KJ, Frigerio M, Manaviazar S.
    Journal: Org Lett; 2001 Nov 15; 3(23):3791-4. PubMed ID: 11700140.
    Abstract:
    [reaction--see text] An 18-step asymmetric synthesis of the bryostatin 1 "southern hemisphere" fragment (1) has been developed. Key steps include an aldol reaction between 6 and 7 and a dehydration to establish the (E)-exocyclic alkene in 2 and a stereoselective Luche reduction and protection with TESOTf to access 1.
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