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  • Title: Surgical treatment of early-infantile epileptic encephalopathy with suppression-bursts associated with focal cortical dysplasia.
    Author: Komaki H, Sugai K, Maehara T, Shimizu H.
    Journal: Brain Dev; 2001 Nov; 23(7):727-31. PubMed ID: 11701286.
    Abstract:
    A surgically treated case of early-infantile epileptic encephalopathy (EIEE) with suppression-bursts associated with focal cortical dysplasia is reported. Tonic-clonic seizures followed by a series of spasms occurred at age of a few days. Interictal electroencephalogram (EEG) revealed a suppression-burst pattern and magnetic resonance imaging suggested focal cortical dysplasia in the left prefrontal area. Combination therapies of antiepileptic treatments showed only partial efficacy. The patient underwent lesionectomy at 4 months of age and the spasms decreased to zero to two series daily. At age 2 years, his seizures increased in number and EEG showed that residual left hemisphere was the main epileptogenic focus. Modified functional hemispherectomy of the left hemisphere was applied at age 3 years. The patient, now 5 years old, is free from seizure and gaining psychomotor development gradually. In cases of EIEE with focal cortical dysplasia, surgical treatment may have beneficial effects on both psychomotor development and seizure control.
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