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  • Title: Fatal rhabdomyolysis caused by lipid-lowering therapy.
    Author: Federman DG, Hussain F, Walters AB.
    Journal: South Med J; 2001 Oct; 94(10):1023-6. PubMed ID: 11702815.
    Abstract:
    Treatment of hypercholesterolemia has been shown to reduce mortality in patients with coronary artery disease. Patients with severe lipid abnormalities may require high-dose statin therapy, at times used in combination with additional agents. We report a case of fatal rhabdomyolysis caused by the combination of simvastatin and gemfibrozil. Clinicians should be aware of risk factors for rhabdomyolysis, which include underlying renal insufficiency, high-dose statin therapy, and combination therapy with a fibrate.
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