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  • Title: Effect of ethanol on tracheal potassium channels reconstituted into bilayer lipid membranes.
    Author: Kominková V, Magova M, Mojzisová A, Maleková E, Ondrias K.
    Journal: Physiol Res; 2001; 50(5):507-11. PubMed ID: 11702855.
    Abstract:
    We examined the effect of ethanol on single potassium channels derived from plasma membranes of bovine tracheal smooth muscles. The observed potassium channels had a conductance of 296 +/- 31 pS (mean +/- S.D.) in symmetrical 250 mmol/l KCl solutions, and exhibited a voltage- and Ca2+-dependence similar to BKCa channels. Ethanol at 50, 100 and 200 mM concentrations increased the probability of open potassium channels to 112 +/- 5, 127 +/- 7 and 121 +/- 13% (mean +/- S.E.M.), respectively. It is suggested that increased activity of the BKCa channels by ethanol hyperpolarizes the plasma membrane and thus may contribute to relaxation of tracheal smooth muscle.
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