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  • Title: Malignant transformation of multiple dermal cylindromas.
    Author: Durani BK, Kurzen H, Jaeckel A, Kuner N, Naeher H, Hartschuh W.
    Journal: Br J Dermatol; 2001 Oct; 145(4):653-6. PubMed ID: 11703297.
    Abstract:
    Cylindromas are benign tumours arising as small, solitary, slow-growing nodules on the head and neck. Multiple cylindromas may form a 'turban tumour' in the autosomal dominant Brooke-Spiegler syndrome. We report two unusual cases of multiple cylindromas with transformation into cylindrocarcinomas. The first patient, a 63-year-old white woman, developed a cylindrocarcinoma on pre-existing multiple cylindromas on her right shoulder. Eight months after resection she developed a lymph node metastasis in the right axilla. The second patient, a 68-year-old white woman, presented with multiple cylindromas of the scalp. One of these transformed into a cylindrocarcinoma, infiltrating the dura mater, with local recurrence 2 years after incomplete resection and postoperative radiation.
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