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  • Title: Dramatic improvement of POEMS syndrome following autologous haematopoietic cell transplantation.
    Author: Rovira M, Carreras E, Bladé J, Graus F, Valls J, Fernández-Avilés F, Montserrat E.
    Journal: Br J Haematol; 2001 Nov; 115(2):373-5. PubMed ID: 11703338.
    Abstract:
    POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, serum monoclonal protein and skin changes) is a rare plasma cell disorder of unknown pathogenesis and is diagnosed by the demonstration of a plasma cell proliferation at the biopsy of an osteoesclerotic lesion. When the lesions are in a limited area, radiation therapy is usually highly effective. Patients with disseminated disease require systemic chemotherapy, which is not effective in most cases. A patient with severe widespread POEMS syndrome resistant to melphalan who experienced a dramatic improvement after high-dose melphalan followed by autologous haematopoietic cell transplantation (AHCT) is reported. We believe that this is the first reported case of POEMS syndrome treated with AHCT, a procedure that could be considered in similarly affected patients.
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